A stereodivergent and diastereoselective transition-metal-catalyzed intramolecular hydroam...
A stereodivergent and diastereoselective transition-metal-catalyzed intramolecular hydroamidation of allenes and alkynes furnishing vinyl-lactams is reported. Employing a rhodium catalyst allowed for the selective synthesis of the syn lactam. Conversely, a palladium catalyst led to the formation of the anti-lactam in high selectivity. The new method shows high functional group compatibility and assorted synthetic transformations were demonstrated as well as its utility for the enantioselective formal total syntheses of cermizine C and senepodine G